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Microfocused Ultrasound: Scientifically Proven Collagen Stimulation

  • Aesthetic Dermatology, Liftera, Rio de Janeiro
Discover how microfocused ultrasound stimulates collagen, promotes firmness and skin rejuvenation with proven effectiveness. Understand how this advanced and safe treatment works and its benefits.

Microfocused ultrasound is an advanced, non-invasive technology that has revolutionized aesthetic treatments by providing skin firmness and rejuvenation. Unlike other techniques, microfocused ultrasound acts deeply, directly stimulating collagen production. This blog discusses how microfocused ultrasound works, detailing the neocollagenesis process and presenting scientific evidence that proves the efficacy and safety of this treatment.

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Table of Contents

How Microfocused Ultrasound Works

Microfocused ultrasound uses ultrasound waves that pass through the skin's surface without causing visible damage and penetrate deeper layers. The technology creates thermal coagulation points at depths ranging from 1.5 mm, 3.0 mm, and 4.5 mm, reaching the dermal and subdermal layers. These points cause controlled thermal damage that triggers a natural tissue repair process and the production of new collagen fibers, called neocollagenesis (Sasaki & Tevez, 2012³; Gutowski, 2016²; Dierickx, 2006³).

This mechanism is highly safe, as the ultrasound waves are focused on specific areas of the skin, preserving the superficial layers. Studies prove that the ideal temperature for collagen stimulation occurs between 60°C and 70°C. At this temperature, the collagen fibers already present undergo a denaturation process and activation of fibroblasts, the cells responsible for collagen production (Alster & Lupton, 2007⁷; Wulkan, Fabi & Green, 2016⁴).

  • Liftera or Ultraformer? Which is the best microfocused ultrasound? Click here!

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The Science Behind Collagen Production: Neocollagenesis

Microfocused ultrasound deeply heats the skin, promoting the creation of new collagen and resulting in firmer, younger-looking skin.

Collagen production after microfocused ultrasound occurs in a process known as neocollagenesis, which is triggered by controlled thermal injury in the deeper layers of the skin. Fibroblasts, activated by heat, initiate collagen regeneration, reorganizing fibers and increasing skin density and firmness over the weeks. The formation of new fibers occurs gradually and reaches its peak between 4 and 6 months after treatment, with results that can extend up to 6 months, or one year after the treatment (Pissurno, 2022⁵; Dos Santos Vianna Néri et al., 2022¹).

The action of microfocused ultrasound is further aided by the production of heat shock proteins (HSPs). These proteins are activated by the increase in temperature and help in cellular recovery, stabilizing newly produced collagen and promoting skin structure. Studies indicate that this process can significantly increase skin firmness, especially in areas of the face and neck, where collagen loss becomes more evident with aging (Gutowski, 2016²; Dierickx, 2006⁸).

  • Before and After Photos | Liftera, Biostimulator, Profhilo, Skinbooster | Click here!

Scientifically Proven Benefits of Microfocused Ultrasound

Studies and clinical reviews demonstrate that microfocused ultrasound offers significant and lasting benefits for facial and body rejuvenation. Microfocused ultrasound not only improves skin firmness but also slows down aging.

Below are the main scientifically proven benefits:

  1. Firmness and ElasticityMicrofocused ultrasound promotes a significant improvement in skin firmness, especially in areas with mild to moderate sagging. The production of collagen and elastin in the deeper layers provides a natural lifting effect (Pissurno, 2022⁵; Luccia & Gotardo, 2023⁶; Dos Santos Vianna Néri et al., 2022¹).

  2. Preventive Effect against AgingSince the treatment stimulates collagen production, it can slow down the aging process by strengthening the skin's structure. Ultrasound acts as an "active prevention" against sagging and wrinkles, providing a younger and more natural appearance (Luccia & Gotardo, 2023⁶).

  3. Long-lasting resultsThe effects of microfocused ultrasound are long-lasting, with results that can last up to a year and a half after a single session. The duration of the results may vary depending on the individual response and skin type, but studies show that collagen production remains active for months (Gutowski, 2016²; Sasaki & Tevez, 2012³).

  4. Effectiveness in Different Areas of the BodyMicrofocused ultrasound is not limited to the face; it can be used on areas such as the neck, arms, abdomen, and thighs, providing firmness to body areas that suffer from sagging (Dos Santos Vianna Néri et al.1, 2022; Pissurno, 2022⁵).

  5. Compatibility with BiostimulatorsMicrofocused ultrasound can be combined with collagen biostimulators, such as Sculptra® and poly-L-lactic acid, amplifying treatment results and providing greater density and elasticity to the skin (Lobo et al., 2023⁹; Dal Piva & Fraporti, 2024¹⁰).

  • Liftera 2 vs Liftera 1: What's the Difference? Click here!

What to Expect During and After Microfocused Ultrasound Treatment?

During treatment, the patient may feel a slight warming sensation and a feeling of pressure, which vary according to the depth of application and individual sensitivity. The procedure is well tolerated by most patients and does not require a recovery period. Side effects, when they occur, are mild, such as redness or temporary swelling (Sasaki & Tevez, 2012³; Alster & Lupton, 2007⁷; Dierickx, 2006⁸).

Results begin to appear from the third month and continue to improve gradually until 6 months after application. Each person responds uniquely to the treatment, influenced by factors such as age, genetics and lifestyle (Gutowski, 2016²; Dos Santos Vianna Néri et al., 2022¹).

  • Liftera 2: What is it for and how does it work? Click here!

Conclusion: Maintain Your Rejuvenation with Liftera

Microfocused ultrasound is a scientifically proven and safe option for those seeking skin rejuvenation and firming without resorting to invasive surgery. The technology acts directly on collagen production, promoting natural and long-lasting results. When combined with biostimulators, the treatment is even more effective, bringing visible benefits to the face, neck, and body areas.

Backed by numerous studies and clinical reviews, microfocused ultrasound stands out as an effective method for combating sagging skin and improving skin quality. Its safety, efficacy, and duration of results make it a solid choice for those seeking visible, scientifically-backed rejuvenation.

  • Sculptra or Liftera: What's the difference? Which is better? Click here!

Reference:

  1. DOS SANTOS VIANNA NÉRI, J. et al. APPLICATION OF MICROFOCUSED ULTRASOUND IN FACIAL REJUVENATION: A LITERATURE REVIEW. International Journal of Science Dentistry, v. 1, n. 60, p. 137–146, 2022. DOI: https://doi.org/10.22409/ijosd.v1i60.54172
  2. GUTOWSKI, K. A. Microfocused ultrasound for skin tightening. Clinics in plastic surgery, vol. 43, no. 3, p. 577–582, 2016. DOI: https://sci-hub.se/10.1016/j.cps.2016.03.012
  3. SASAKI, GH; TEVEZ, A. Microfocused ultrasound for nonablative skin and subdermal tightening to the periorbitum and body sites: Preliminary report on eighty-two patients. Journal of Cosmetics Dermatological Sciences and Applications, v. 02, no. 02, p. 108–116, 2012. DOI: http://dx.doi.org/10.4236/jcdsa.2012.222022
  4. WULKAN, AJ; FABI, SG; GREEN, J.B. Microfocused ultrasound for facial photorejuvenation: A review. Facial plastic surgery: FPS, v. 32, no. 3, p. 269–275, 2016. http://dx.doi.org/10.1055/s-0036-1584129
  5. Pissurno, L. de L. (2022)Microfocused ultrasound: biotechnology in the service of aesthetics, creating a breakthrough in chronological aging and improving appearance. of tissue flaccidity. 
  6. Luccia, F. di, & Gotardo, L. . (2023). The efficacy of microfocused ultrasound in skin aging. Scientific Journal of Aesthetics and Cosmetology, 3(1), E1062023 – 1. https://doi.org/10.48051/rcec.v3i1.106
  7. Alster, T.S., & Lupton, J.R. (2007). Nonablative Cutaneous Remodeling Using Radiofrequency Devices. Clinics in Dermatology. DOI: http://dx.doi.org/10.4236/jcdsa.2012.222022
  8. Dierickx, CC (2006). The Role of Deep Heating for Noninvasive Skin Rejuvenation. Lasers in Surgery and Medicine. DOI: http://dx.doi.org/10.1002/lsm.20446.
  9. Lobo, B., et al. (2023). Association of Sculptra with Microfocused Ultrasound for Facial Rejuvenation. Health and Society, 3, 496-506. DOI: https://doi.org/10.51249/hs.v3i06.1795
  10. Dal Piva, AKF, & Fraporti, L. (2024). Collagen BiostimulatorJournal of the FAI University Center – UCEFF Itapiranga – SC, Health Sciences Center, 3(1), Extended Abstract. DOI: https://revistas.uceff.edu.br/reviva/article/view/400/524
  • Facial Rejuvenation Protocol: Liftera, Biostimulator and Botox | Click here!
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Medical evaluation is essential to understand the patient's complaints, identify dermatological problems, and consider their individual characteristics, such as anatomy, skin type, and reactions to substances used. Based on this, it is possible to determine the appropriate techniques to naturally enhance the features of the face, skin, and body.

Choosing a dermatologist is crucial for a thorough analysis of the areas of disharmony in the patient and to determine the necessary techniques, whether it be increasing volume, correcting angles, or symmetry. With a personalized and exclusive treatment plan, it is possible to meet the specific needs of each patient while respecting their limitations.

Dr. Renata Ralha, Clinical, Aesthetic and Hair Dermatologist, CRM: 52-84102-1 RJ, RQE No.: 28115

Dermatological Consultation

Medical evaluation is essential to understand the patient's complaints, identify dermatological problems, and consider their individual characteristics, such as anatomy, skin type, and reactions to substances used. Based on this, it is possible to determine the appropriate techniques to naturally enhance the features of the face, skin, and body.

Choosing a dermatologist is crucial for a thorough analysis of the areas of disharmony in the patient and to determine the necessary techniques, whether it be increasing volume, correcting angles, or symmetry. With a personalized and exclusive treatment plan, it is possible to meet the specific needs of each patient while respecting their limitations.

Dr. Renata Ralha, Clinical, Aesthetic and Hair Dermatologist, CRM: 52-84102-1 RJ, RQE No.: 28115

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Name: Dr. Renata Ralha, Clinical, Aesthetic and Hair Dermatologist

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